In Milwaukee, a series of women have been found murdered with their hearts crudely removed. The BAU is assigned to the case, but they are short three members: Gideon, who is missing, Hotch, who is on suspension and Prentiss, who resigns her commission to join the Foreign Service. Supervisor Strauss steps in as lead, but she doesn't handle herself well in the field.
The BAU is called to West Bune, a small town in Texas, to investigate what appears to be spree killings that involve a teenaged boy and his girlfriend.
The team members try to identify a stalker before he can attack a woman who is being stalked in Silver Spring, Maryland. Meanwhile, Hotch and Rossi are called as consultants on a possible battered woman syndrome murder case in Boston.
After a suspected serial killer wakes up from a coma, the BAU reopens the case and uses brain fingerprinting to determine if he really doesn't remember the crimes that had been committed four years earlier in Roanoke, Virginia.
The BAU faces one of its toughest cases when the team is called to New York City to determine if a series of random shootings is the work of one serial killer or a team of killers working together.
An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.